# README — Neuroinflammation and Neurodegenerative Disorders
## Integrated Molecular Biomarkers, Neuroimaging and Clinical Progression Data
## Version 2 | 2026-03-19

DOI: https://doi.org/10.7910/DVN/X2TQQA
Author: de la Serna, Juan Moises (UNIR) | ORCID: 0000-0002-8401-8018
License: CC0 1.0 Universal

## Description
Comprehensive database integrating molecular biomarkers, neuroimaging data, and clinical
progression scales for three major neurodegenerative disorders: Alzheimer (AD),
Parkinson (PD), and Multiple Sclerosis (MS), with focus on neuroinflammatory mechanisms.
Data from peer-reviewed literature, meta-analyses and global health reports (2013-2026).

## Dataset Contents
| File | Description | Variables | Observations |
|------|-------------|-----------|--------------|
| Neuroinflammation_Neurodegenerative_Disorders_Database.csv | Main data | 11 | 89 |
| README.md | This file |
| CODEBOOK.md | Variable dictionary |
| METHODOLOGY.md | Data collection protocol |
| CHANGELOG.md | Version history |
| references.csv | Structured bibliography (15 sources) |

## Data Categories (89 records across 8 categories)
1. Molecular biomarkers CSF/blood: cytokines (IL-1b, IL-6, IL-8, TNF-a, IFN-g, TGF-b),
   amyloid-beta 42, tau, phospho-tau, alpha-synuclein, NfL, GFAP, YKL-40
2. Neuroimaging: MRI volumetrics, amyloid PET, FDG-PET, DAT-SPECT, T2-FLAIR lesions
3. Clinical progression scales: CDR (AD), UPDRS (PD), EDSS (MS)
4. Epidemiology: global prevalence, sex ratios, age distribution, survival
5. Genetic risk factors: APOE e4, LRRK2, GBA, HLA-DRB1 (odds ratios)
6. Approved drugs: efficacy data from Phase III trials
7. Clinical trials (2020-2024): anti-neuroinflammatory therapies
8. Economic burden: global annual costs (billion USD)

## Key Findings
- IL-6 levels in CSF: AD ~11.2 pg/mL vs. controls ~2.1 pg/mL (5x elevation)
- NfL (neurofilament light chain) elevated in all three disorders vs. controls
- APOE e4 homozygous: OR ~14 for AD development
- Global economic burden: AD/dementia ~$1.3 trillion USD/year (2022)

## How to Cite
de la Serna, Juan Moises, 2026, "Neuroinflammation and Neurodegenerative Disorders",
https://doi.org/10.7910/DVN/X2TQQA, Harvard Dataverse.